翻訳と辞書 Words near each other ・ Chaplinsky v. New Hampshire ・ Chaplujeh ・ Chaplygin ・ Chaplygin (crater) ・ Chaplygin (inhabited locality) ・ Chaplygin gas ・ Chaplygin problem ・ Chaplygin sleigh ・ Chaperal, Ottawa ・ Chaperina fusca ・ Chaperon (headgear) ・ Chaperone ・ Chaperone (clinical) ・ Chaperone (protein) ・ Chaperone (social) ・ Chaperone code ・ Chaperone DnaJ ・ Chaperone-assisted selective autophagy ・ Chaperone-mediated autophagy ・ Chaperone-Usher fimbriae ・ Chaperonin ・ Chaperonin ATPase ・ Chapeshlu ・ Chapeshlu District ・ Chapet ・ Chapey ・ Chapfensee ・ Chapi ・ Chapi (Peru) ・ Chapi Chapo Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Chaperone code ： ウィキペディア英語版 Chaperone code The Chaperone code has been identified as one of the main regulatory mechanisms underlying cell function in biology. While the genetic code specifies how DNA makes proteins, while the histone code rules genomic transactions, the chaperone code stipulates how proteins produce a functional proteome. The chaperone code refers to the combinatorial array of posttranslational modifications - i.e. phosphorylation, acetylation, ubiquitination, methylation, etc - that target molecular chaperones to modulate their activity. Molecular chaperones are proteins specialized in folding and unfolding of the other cellular proteins and assembly and dismantling of protein complexes, thereby orchestrating the dynamic organization of the proteome. As a consequence, a limited number of chaperones must be able to act on a very large number of substrates in a highly regulated manner. The chaperone code concept posits that combinations of posttranslational modifications at the surface of chaperones, including phosphorylation, acetylation, methylation, ubiquitination, etc, control protein folding/unfolding and protein complex assembly/disassembly by stipulating substrate specificity, activity, subcellular localization and co-factor binding. This conclusion emerges from the analysis of nearly two hundred reports in the literature,〔Cloutier and Coulombe 2013 Biochim Biophys Acta; doi:pii: S1874-9399(13)00042-4. 10.1016/j.bbagrm.2013.02.010.〕 including a key article published in 2013 reporting on the discovery of a novel family of methyltransferases that preferentially target and regulate molecular chaperones.〔Cloutier et al 2013 PLoS Genetics 9, e1003210.〕 Because posttranslational modifications are marks that can be added and removed rapidly, they provide an efficient mechanism to explain the plasticity observed in proteome organization during cell growth and development. A large number of diseases, including degenerative neuromuscular disorders and cancer, are associated with dysfunction of molecular chaperones. Decrypting and reprogramming the chaperone code represents a gigantic initiative that generates new hopes for the development of therapeutics for degenerative diseases. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Chaperone code」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.